Smedslund Geir, Mowinckel Petter, Heiberg Turid, Kvien Tore Kristian, Hagen Kåre Birger
National Resource Centre for Rehabilitation in Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Arthritis Rheum. 2009 Sep 15;61(9):1243-7. doi: 10.1002/art.24729.
To explore how reported joint pain in patients with rheumatoid arthritis (RA) relates to weather and solar variables.
A prospective cohort study was conducted in Norway on 36 patients with stable RA. Daily reports of pain in the morning on a visual analog scale for 84 consecutive days were correlated (using time-series methodology) with records of atmospheric and solar variables for the same days.
Pain was significantly associated with 3 or more external variables in 6 (17%) of the patients, with 1 or 2 external variables in 16 (44%) of the patients, and no associations were observed in 14 (39%) of the patients. The multivariate model explained between 19% and 64% of the variance in pain (R(2)) in the patients with associations to at least 3 weather/solar variables. The patients differed in the variables they responded to and in which direction, except for consistent negative associations between pain and ultraviolet light dose, and between pain and solar radio flux/sunspot count. The associations were mostly with same-day weather, but also lagged up to 3 days. We were not able to fit a statistically significant model at the group level.
Weather sensitivity seems to be a continuum and a highly individual phenomenon in patients with RA. In the present sample, pain was significantly associated with 3 or more weather variables in 1 out of 6 patients, for whom the magnitude of weather sensitivity might significantly influence pain reporting in clinical care and research.
探讨类风湿关节炎（RA）患者报告的关节疼痛与天气和太阳变量之间的关系。
在挪威对36例病情稳定的RA患者进行了一项前瞻性队列研究。连续84天每天用视觉模拟量表报告早晨的疼痛情况，并（使用时间序列方法）将其与同一天的大气和太阳变量记录进行关联分析。
6例（17%）患者的疼痛与3个或更多外部变量显著相关，16例（44%）患者的疼痛与1个或2个外部变量显著相关，14例（39%）患者未观察到相关性。在与至少3个天气/太阳变量有关联的患者中，多变量模型解释了疼痛方差（R²）的19%至64%。除了疼痛与紫外线剂量之间以及疼痛与太阳射电流量/太阳黑子数之间存在一致的负相关外，患者对不同变量的反应及其方向各不相同。这些关联大多与当日天气有关，但也有滞后长达3天的情况。我们未能在组水平上拟合出具有统计学意义的模型。
天气敏感性在RA患者中似乎是一个连续体且是高度个体化的现象。在本样本中，6例患者中有1例的疼痛与3个或更多天气变量显著相关，对于这些患者，天气敏感性的程度可能会在临床护理和研究中显著影响疼痛报告。
