Department of Rheumatology, Colmar General Hospital, Colmar, France.
Department of Public Health, GMRC, Strasbourg University Hospital, Strasbourg, France.
Arthritis Res Ther. 2020 Feb 24;22(1):39. doi: 10.1186/s13075-020-2118-1.
To assess the presence of a seasonal effect on fatigue, pain and dryness in primary Sjögren's syndrome (pSS).
Data (date; visual analogue scales (VAS) for pain, fatigue and dryness) were extracted from three randomised placebo-controlled trials (RCTs) evaluating infliximab (TRIPSS; n = 103 patients), hydroxychloroquine (JOQUER; n = 120 patients) and rituximab (TEARS; n = 120 patients) and from the 5-year follow-up of the ASSESS prospective cohort (n = 395 patients). Data were analysed at each visit for each patient, according to the day, the month of the year and the season. Linear mixed models were used to take into account the repeated structure of the data and to analyse a potential cyclic effect.
A total of 744, 584, 848 and 682 pain, fatigue and dryness VASs were collected on 632 subjects in spring, summer, fall and winter, respectively. No significant difference was observed in pain, fatigue and dryness, according to the month of the year or the season (all p values > 0.05).
In pSS, seasonality does not affect patient-reported outcomes (PROs) on fatigue, pain and dryness.
评估原发性干燥综合征（pSS）患者疲劳、疼痛和干燥感是否存在季节性影响。
从三项评估英夫利昔单抗（TRIPSS；n=103 例患者）、羟氯喹（JOQUER；n=120 例患者）和利妥昔单抗（TEARS；n=120 例患者）的随机安慰剂对照试验（RCT）以及前瞻性队列 ASSESS 研究的 5 年随访（n=395 例患者）中提取数据（日期；疼痛、疲劳和干燥的视觉模拟量表（VAS））。根据每位患者的每次就诊日期、月份和季节对数据进行分析。线性混合模型用于考虑数据的重复结构，并分析潜在的周期性影响。
共收集了 632 例患者在春季、夏季、秋季和冬季的 744、584、848 和 682 次疼痛、疲劳和干燥 VAS。根据年份的月份或季节，疼痛、疲劳和干燥均无显著差异（所有 p 值>0.05）。
在 pSS 中，季节变化不会影响疲劳、疼痛和干燥等患者报告的结局（PROs）。
