Evans S M, Zacny J P, Johanson C E
Department of Psychiatry, Pritzker School of Medicine, University of Chicago, IL 60637.
Pharmacol Biochem Behav. 1990 Apr;35(4):971-80. doi: 10.1016/0091-3057(90)90387-w.
Five pigeons were trained to discriminate among (+)-amphetamine (AMPH; 1.7 or 3.0 mg/kg), fenfluramine (FEN; 5.6 or 10 mg/kg), and saline using a three-choice drug discrimination procedure. The results of the study demonstrated that a reliable discrimination between AMPH and FEN could be obtained and the discriminative stimulus (DS) effects of these two drugs did not overlap, i.e., were mutually exclusive. Phenmetrazine produced a dose-related increase in AMPH-appropriate responding with no responding occurring on the FEN-appropriate key. Two serotonin agonists, quipazine (5-HT2) and MK 212 (5-HT1), produced FEN-appropriate responding in two of three pigeons, while a third pigeon responded predominantly on the AMPH-appropriate key following their administration. In contrast, phencyclidine produced predominantly (greater than 50%) saline-appropriate responding, indicating that the DS effect of phencyclidine was unlike either AMPH or FEN. Finally, compounds known to have multiple DS properties such as MDA and MDMA were tested. The results with these compounds confirmed that these drugs have complex DS effects both within and across individual pigeons.
五只鸽子接受训练，采用三选一药物辨别程序，以区分（+）-苯丙胺（AMPH；1.7或3.0毫克/千克）、芬氟拉明（FEN；5.6或10毫克/千克）和生理盐水。研究结果表明，AMPH和FEN之间能够获得可靠的辨别，且这两种药物的辨别刺激（DS）效应不重叠，即相互排斥。苯甲吗啉使对AMPH的适当反应呈剂量相关增加，而对FEN的适当按键无反应。两种5-羟色胺激动剂，喹哌嗪（5-HT2）和MK 212（5-HT1），在三只鸽子中的两只身上产生了对FEN的适当反应，而第三只鸽子在给药后主要对AMPH的适当按键做出反应。相比之下，苯环利定主要产生（超过50%）对生理盐水的适当反应，表明苯环利定的DS效应与AMPH或FEN均不同。最后，对已知具有多种DS特性的化合物如MDA和MDMA进行了测试。这些化合物的结果证实，这些药物在个体鸽子内部和个体之间均具有复杂的DS效应。
