硬膜外镇痛后中枢神经系统曲霉病感染：诊断、治疗挑战及文献回顾。
Central nervous system Aspergillus infection after epidural analgesia: diagnosis, therapeutic challenges, and literature review.
机构信息
Department of Laboratory Medicine, Yale University School of Medicine, P.O. Box 208035, New Haven, CT 06520-8035, USA.
出版信息
Diagn Microbiol Infect Dis. 2009 Nov;65(3):312-8. doi: 10.1016/j.diagmicrobio.2009.06.013. Epub 2009 Aug 29.
Abstract
Aspergillus terreus was identified in an intradural spinal biopsy specimen from an African female with recurrent headache and hydrocephalus. Prior laboratory testing of cerebrospinal fluid was nondiagnostic, despite extensive central nervous system (CNS) involvement. CNS Aspergillus infection presents a diagnostic and therapeutic challenge and is reviewed in the context of this particularly instructive and difficult case.
摘要
从一名患有复发性头痛和脑积水的非洲女性的硬脑膜脊髓活检标本中鉴定出土曲霉。尽管中枢神经系统（CNS）广泛受累，但先前对脑脊液的实验室检测没有明确诊断。中枢神经系统曲霉病提出了诊断和治疗方面的挑战，本病例特别具有启发性和难度，因此对此进行了回顾。
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Neurology. 2008 Jun 10;70(24 Pt 2):2411-3. doi: 10.1212/01.wnl.0000314690.18731.1b.
4
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5
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