Cokkinos Dennis V, Pantos Constantinos
Département de Cardiologie, Centre Onassis de Chirurgie Cardiaque, 356, Sygrou Avenue, Athènes 17 674- Grèce.
Bull Acad Natl Med. 2009 Feb;193(2):327-36; discussion 336-8.
Thyroid hormones are closely related to cardiac structure and function. We have been studying their effects for over 15 years in various experimental models:--Daily triidothyronin (T3) administration to rats for 14 days improves the ability of the isolated heart to tolerate ischemia, without abolishing the capacity for ischemic preconditioning (IP).--When hypothyroidism is induced in rats by administering propylthiouracil for 21 days, the isolated heart is markedly more tolerant of 30 min of global ischemia but can no longer undergo IP.--After myocardial infarction induced in rats by left coronary artery ligation, the post--infarct heart is protected against global ischemia but its contractility is reduced. T3 administration for 2 and 13 weeks significantly improves contractility and reduces both remodeling and the sphericity index.--TNF exposure delays cultured neonatal rat myocyte elongation (maturation), and this effect is prevented by concomitant T3 administration.--Thus, thyroid hormones offer valuable insights into cardiac structure and function and may have therapeutic potential in patients with cardiovascular disease.
甲状腺激素与心脏结构和功能密切相关。我们在各种实验模型中研究它们的作用已超过15年：——每天给大鼠注射三碘甲状腺原氨酸（T3），持续14天，可提高离体心脏耐受缺血的能力，同时不消除缺血预处理（IP）的能力。——当给大鼠连续21天注射丙硫氧嘧啶诱导甲状腺功能减退时，离体心脏对30分钟全心缺血的耐受性明显增强，但不再能进行缺血预处理。——通过左冠状动脉结扎诱导大鼠心肌梗死后，梗死后期心脏对全心缺血有保护作用，但其收缩力降低。注射T3 2周和13周可显著改善收缩力，并减少重塑和球形指数。——肿瘤坏死因子（TNF）暴露会延迟培养的新生大鼠心肌细胞伸长（成熟），同时注射T3可防止这种作用。——因此，甲状腺激素为心脏结构和功能提供了有价值的见解，可能对心血管疾病患者具有治疗潜力。
