Department of Pharmacology, University of Athens, School of Medicine, 75 Mikras Asias Ave., 11527 Goudi, Athens, Greece.
Vascul Pharmacol. 2010 Mar-Apr;52(3-4):157-65. doi: 10.1016/j.vph.2009.11.006. Epub 2009 Nov 29.
Thyroid hormone (TH), apart from its "classical" actions on cardiac contractility and heart rhythm, appears to regulate various intracellular signalling pathways related to response to stress and cardiac remodelling. There is now accumulating experimental and clinical evidence showing a beneficial effect of TH on limiting myocardial ischaemic injury, preventing/reversing post infarction cardiac remodelling and improving cardiac hemodynamics. Thyroid analogs have already been developed and may allow TH use in clinical practice. However, the efficacy of TH in the treatment of cardiac diseases is now awaiting to be tested in large clinical trials.
甲状腺激素（TH）除了对心脏收缩力和心律有“经典”作用外，似乎还调节与应激反应和心脏重构相关的各种细胞内信号通路。目前有越来越多的实验和临床证据表明，TH 对限制心肌缺血损伤、预防/逆转梗死后心脏重构和改善心脏血液动力学有有益作用。已经开发出了甲状腺类似物，这可能允许在临床实践中使用 TH。然而，TH 在治疗心脏疾病方面的疗效仍有待大型临床试验来检验。
