[How do beta receptor blockers modify physical performance and metabolism?].

Beta-blockers reduce physical capacity and lead to an increased sensation of muscular fatigue. The limits of endurance capacity, which is important for both leisure-sports and fitness, are set primarily by metabolic factors, because the energy liberation via the metabolism of lipids and carbohydrates is reduced as a result of the inhibition of lipolysis and glycogenolysis. Beta 1-selective blockers influence the physical capacity less effectively on any intensity level as non-selective blockers do. The latter may lead to hypoglycemic reactions. Beta-blockers with intrinsic sympathicomimetic activity (ISA) are not superior to others. Physically active patients should be treated with beta 1-selective blockers.