Guan Jing, Ni Dao-feng, Wang Jian, Gao Zhi-qiang
Department of Otolaryngology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, China.
Chin Med J (Engl). 2009 Jul 5;122(13):1554-7.
Subjective olfactory tests are easy to perform and popularly applied in the clinic, but using only these, it is difficult to diagnose all disorders of the olfactory system. The olfactory event related potentials technique offers further insight into the olfactory system and is an ideal objective test. This analysis was of subjective and objective data on the olfactory function of twelve patients with loss of smell associated with an upper respiratory infection (URI).
We tested the twelve patients with URI induced olfactory loss by medical history, physical examination of the head and neck, olfactory tests and medical imaging. Olfactory function was assessed by Toyota and Takagi olfactometry including olfactory detection and recognition thresholds and olfactory event-related potentials (OERPs) recorded with OEP-98C Olfactometer.
An unusual phenomenon was observed in five patients in whom the subjective detection and recognition thresholds were normal, while the expected OERPs were not detectable.
We suggest that the discordance between olfactory psychophysical measurements and OERPs might be the results of abnormal electrophysiology related with olfactory neuropathy caused by viral URI. In addition, the measurement of OERPs might play a significant role in evaluating olfactory dysfunction.
主观嗅觉测试易于实施且在临床上广泛应用，但仅依靠这些测试，很难诊断所有嗅觉系统疾病。嗅觉事件相关电位技术能更深入地了解嗅觉系统，是一种理想的客观测试方法。本分析针对12例因上呼吸道感染（URI）导致嗅觉丧失患者的主观和客观嗅觉功能数据展开。
我们通过病史、头颈部体格检查、嗅觉测试和医学成像对12例因URI导致嗅觉丧失的患者进行了检测。嗅觉功能通过丰田和高木嗅觉测量法进行评估，包括嗅觉检测和识别阈值，以及使用OEP - 98C嗅觉仪记录的嗅觉事件相关电位（OERP）。
在5例患者中观察到一种异常现象，其主观检测和识别阈值正常，但预期的OERP却无法检测到。
我们认为嗅觉心理物理学测量与OERP之间的不一致可能是由病毒性URI引起的嗅觉神经病变相关的异常电生理结果。此外，OERP测量在评估嗅觉功能障碍中可能发挥重要作用。
