Cui L, Evans W J
Department of Neurology, Peking Union Medical College Hospital, Beijing.
Zhonghua Yi Xue Za Zhi. 1998 Aug;78(8):588-90.
To investigate the olfactory origin of the event-related potential (OEP) by evaluating OEP and standardized psychophysical measures in patients with congenital anosmia.
Olfactory function was evaluated by OEP and standardized psychophysical measures including smell identification test and odor detection threshold tests for 3 chemosensory stimulants: phenylethyl alcohol (PEA), isoamyl acetate (IAA), and chloracetyl phenone (CAP) in 9 subjects with isolated congenital anosmia and 9 age- and gender-matched normosmic controls.
There was a significant difference in the smell identification test score (P < 0.001) and odor detection thresholds for PEA and IAA (P < 0.001) between the anosmic and normosmic subjects. Detection thresholds for CAP, a trigeminal stimulant, did not differ between the 2 groups. In the control subjects, OEP to IAA was characterized by 4 reproducible components (P1, N1, P2 and N2). In the subjects with congenital anosmia, no reproducible evoked potential components were identified in response to IAA. No reproducible evoked potential components were seen in response to the air control stimulus in either the anosmic or normosmic groups.
These data suggest that OEP provide a specific and objective measure of olfactory function.
通过评估先天性嗅觉缺失患者的事件相关电位（OEP）和标准化心理物理学指标，研究OEP的嗅觉起源。
采用OEP和标准化心理物理学指标，包括嗅觉识别测试以及对三种化学感觉刺激物（苯乙醇（PEA）、乙酸异戊酯（IAA）和氯乙酰苯（CAP））的气味检测阈值测试，对9例孤立性先天性嗅觉缺失患者和9例年龄及性别匹配的嗅觉正常对照者的嗅觉功能进行评估。
嗅觉缺失组和嗅觉正常组在嗅觉识别测试得分（P < 0.001）以及PEA和IAA的气味检测阈值（P < 0.001）方面存在显著差异。两组之间三叉神经刺激物CAP的检测阈值无差异。在对照者中，对IAA的OEP具有4个可重复成分（P1、N1、P2和N2）。在先天性嗅觉缺失患者中，对IAA未识别出可重复的诱发电位成分。在嗅觉缺失组或嗅觉正常组中，对空气对照刺激均未观察到可重复的诱发电位成分。
这些数据表明OEP为嗅觉功能提供了一种特异且客观的测量方法。
