Ma Yi-Tong, Xie Xiang, Fu Zhen-Yan, Yang Yi-Ning, Ma Xiang, Wang Ying-Hong, Chen Bang-Dang, Liu Fen
Department of Cardiology, First Affiliated Hospital, Xinjiang Medical University, Urumqi 830011, China.
Zhonghua Xin Xue Guan Bing Za Zhi. 2009 Feb;37(2):115-9.
To investigate the association between the polymorphisms and haplotypes of prostacyclin synthase gene with MI in Uigur patients in Xinjiang.
210 patients with MI and 206 healthy control subjects were genotyped for 3 SNPs of the human prostacyclin synthase gene by polymerase chain reaction and restriction fragment length polymorphism.
The genotype distributions of the control group and MI group were in the Hardy-Weinberg equilibrium (both P > 0.05). The frequency of CC of rs5629 in MI group was significantly higher than that in controls (71.42% vs. 61.65%, P = 0.035). The frequency of A-C-T haplotype was significantly higher in the control group than that in the MI patients (4.01% vs. 0.60%, P = 0.001). The frequency of C-T-T haplotype was significantly higher in the MI patients than that in the controls (7.40% vs. 3.31%, P = 0.011). Logistic regression analysis showed that, after adjusting hypertension, hyperlipemia and smoking, the CC genotype of rs5629 (P = 0.021, OR = 1.665, 95%CI: 1.024 - 2.156) and the C-T-T haplotype (P = 0.011, OR = 1.876, 95%CI: 1.410 - 3.171) was the independent risk factors for MI.
The CC genotype of rs5629 and the C-T-T haplotype of prostacyclin synthase gene are associated with MI but the A-C-T haplotype of prostacyclin synthase gene might be a protective factor of MI in Uigur population of Xinjiang.
探讨新疆维吾尔族患者中前列环素合酶基因多态性及单倍型与心肌梗死（MI）的关系。
采用聚合酶链反应和限制性片段长度多态性技术，对210例MI患者和206例健康对照者的人前列环素合酶基因的3个单核苷酸多态性（SNP）进行基因分型。
对照组和MI组的基因型分布均符合Hardy-Weinberg平衡（均P>0.05）。MI组rs5629位点CC基因型频率显著高于对照组（71.42%对61.65%，P=0.035）。对照组A-C-T单倍型频率显著高于MI患者（4.01%对0.60%，P=0.001）。MI患者C-T-T单倍型频率显著高于对照组（7.40%对3.31%，P=0.011）。Logistic回归分析显示，校正高血压、高脂血症和吸烟因素后，rs5629位点CC基因型（P=0.021，OR=1.665，95%CI：1.024-2.156）和C-T-T单倍型（P=0.011，OR=1.876，95%CI：1.410-3.171）是MI的独立危险因素。
rs5629位点CC基因型和前列环素合酶基因C-T-T单倍型与MI有关，但前列环素合酶基因A-C-T单倍型可能是新疆维吾尔族人群MI的保护因素。
