University of Toronto, Department of Pharmacology, Toronto, Ontario, M5S 1A8, Canada.
Epilepsy Res. 2009 Nov;87(1):40-6. doi: 10.1016/j.eplepsyres.2009.07.007. Epub 2009 Aug 31.
Women with epilepsy often suffer from weight gain. A similar phenomenon is seen in female rats that are kindled from the amygdala. Interestingly, it has been reported that kindling of the left amygdala causes more weight gain than kindling of the right amygdala. The present study was designed to confirm and extend that effect.
Female Wistar rats were kindled from the left or right basolateral amygdala to a criterion of 40 stage 5 seizures. Control subjects were handled but not stimulated. Subjects were weighed weekly for the duration of the study. Twenty-four hours following the last kindled seizure, kindled subjects and their yoked controls were sacrificed and their brains and serum were extracted.
Kindled subjects weighed significantly more than controls at the end of the kindling procedure and had significantly higher serum levels of leptin. No laterality effects were seen in either weight gain or leptin levels, however.
Amygdala kindling increases weight gain and serum leptin levels in rats, but in the present study no laterality effects were seen.
患有癫痫的女性常出现体重增加的情况。在从杏仁核引发的雌性大鼠中也出现了类似的现象。有趣的是，据报道，左侧杏仁核引发比右侧杏仁核引发更容易导致体重增加。本研究旨在证实并扩展这一效应。
雌性 Wistar 大鼠从左侧或右侧基底外侧杏仁核引发至 40 次 5 级癫痫发作的标准。对照组仅进行处理而不进行刺激。在整个研究过程中，每周对受试对象进行称重。在最后一次点燃癫痫发作后的 24 小时内，点燃组和其配对的对照组被处死，并提取其大脑和血清。
在点燃程序结束时，点燃组的体重明显高于对照组，并且血清瘦素水平明显更高。然而，在体重增加或瘦素水平方面均未观察到偏侧效应。
杏仁核引发会增加大鼠的体重增加和血清瘦素水平，但在本研究中未观察到偏侧效应。
