Yamada Yuichiro
Department of Endocrinology, Diabetes and Geriatric Medicine, Akita University Graduate School of Medicine.
Clin Calcium. 2009 Sep;19(9):1312-7.
Gastrointestinal hormones including gastric inhibitory polypeptide (GIP) and glucagon-like peptide (GLP) -1 are incretin, which are secreted immediately after meal ingestion and stimulate insulin secretion from pancreatic beta-cells. Characterization of extra-pancreatic GIP and GLP-1 receptors has revealed that these hormones regulate bone turnover. GIP intermittently stimulates osteoblasts and GLP-1 suppresses osteoclasts through a calcitonin-dependent pathway to increase the bone volume.
包括胃抑制多肽（GIP）和胰高血糖素样肽（GLP）-1在内的胃肠激素是肠促胰岛素，它们在进食后立即分泌，并刺激胰腺β细胞分泌胰岛素。胰腺外GIP和GLP-1受体的特性表明，这些激素调节骨转换。GIP间歇性刺激成骨细胞，而GLP-1通过降钙素依赖途径抑制破骨细胞，从而增加骨量。
