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来自乳香（卡氏乳香树的树脂）的乳香醇A、B、C、H、I和J的绝对立体结构以及脂多糖激活的小鼠腹腔巨噬细胞中一氧化氮产生的抑制剂。

Absolute stereostructures of olibanumols A, B, C, H, I, and J from olibanum, gum-resin of Boswellia carterii, and inhibitors of nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages.

作者信息

Yoshikawa Masayuki, Morikawa Toshio, Oominami Hideo, Matsuda Hisashi

机构信息

Kyoto Pharmaceutical University, Japan.

出版信息

Chem Pharm Bull (Tokyo). 2009 Sep;57(9):957-64. doi: 10.1248/cpb.57.957.

DOI:10.1248/cpb.57.957
PMID:19721256
Abstract

Three new monoterpenes, olibanumols A (1), B (2), and C (3), and three new triterpenes, olibanumols H (4), I (5), and J (6), were isolated from olibanum, the exuded gum-resin from Boswellia carterii BIRDW. Their structures including the absolute configuration were determined by chemical and physicochemical evidence. Among the constituents, olibanumols A (1), H (4), and I (5), and isofouquierol (12) exhibited nitric oxide production inhibitory activity in lipopolysaccharide-activated mouse peritoneal macrophages.

摘要

从乳香（Boswellia carterii BIRDW所分泌的树胶脂）中分离出三种新的单萜类化合物，乳香醇A（1）、B（2）和C（3），以及三种新的三萜类化合物，乳香醇H（4）、I（5）和J（6）。通过化学和物理化学证据确定了它们的结构，包括绝对构型。在这些成分中，乳香醇A（1）、H（4）和I（5）以及异福桂醇（12）在脂多糖激活的小鼠腹腔巨噬细胞中表现出一氧化氮产生抑制活性。

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