Yoshikawa Masayuki, Morikawa Toshio, Oominami Hideo, Matsuda Hisashi
Kyoto Pharmaceutical University, Japan.
Chem Pharm Bull (Tokyo). 2009 Sep;57(9):957-64. doi: 10.1248/cpb.57.957.
Three new monoterpenes, olibanumols A (1), B (2), and C (3), and three new triterpenes, olibanumols H (4), I (5), and J (6), were isolated from olibanum, the exuded gum-resin from Boswellia carterii BIRDW. Their structures including the absolute configuration were determined by chemical and physicochemical evidence. Among the constituents, olibanumols A (1), H (4), and I (5), and isofouquierol (12) exhibited nitric oxide production inhibitory activity in lipopolysaccharide-activated mouse peritoneal macrophages.
从乳香(Boswellia carterii BIRDW所分泌的树胶脂)中分离出三种新的单萜类化合物,乳香醇A(1)、B(2)和C(3),以及三种新的三萜类化合物,乳香醇H(4)、I(5)和J(6)。通过化学和物理化学证据确定了它们的结构,包括绝对构型。在这些成分中,乳香醇A(1)、H(4)和I(5)以及异福桂醇(12)在脂多糖激活的小鼠腹腔巨噬细胞中表现出一氧化氮产生抑制活性。