八角果实中的两个新单萜。

Two new monoterpenes from the fruits of Illicium lanceolatum.

机构信息

School of Pharmaceutical Science, Zhengzhou University, Ke Xue Da Dao 100, Zhengzhou 450001, China.

出版信息

Molecules. 2013 Sep 26;18(10):11866-72. doi: 10.3390/molecules181011866.

DOI:10.3390/molecules181011866

PMID:24077171

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6269894/

Abstract

Two new monoterpenes, p-mentha-1(7),8-dien-2-O-β-D-glucoside and trans-2,4-dihydroxy-2,4-dimethyl-trans-1-acetic acid γ-lactone were isolated from the fruits of Illicium lanceolatum along with trans-2,4-dihydroxy-2,4-dimethyl-cis-1-acetic acid γ-lactone, (1R,2R,4R)-8-p-menthen-1,2-diol, trans-sobrerol, (1S,2S,4R)-p-menthane-1,2,8-triol and (1S, 2S, 4R, 8R)-p-menthane-1,2,9-triol. The structures of the isolates were confirmed by spectroscopic analysis and they showed no inhibitory effects on the in vitro growth of microbial organisms (Escherichia coli, Staphyloccocus aureus, Bacillus subtilis) at less than 1.0 mg/mL.

摘要

从八角茴香果实中分离得到了两种新的单萜类化合物，即 p-薄荷-1(7),8-二烯-2-O-β-D-葡萄糖苷和反式-2,4-二羟基-2,4-二甲基-顺式-1-乙酸γ-内酯，此外还分离得到了反式-2,4-二羟基-2,4-二甲基-反式-1-乙酸γ-内酯、(1R,2R,4R)-8-薄荷烯-1,2-二醇、反式-索布醇、(1S,2S,4R)-薄荷烷-1,2,8-三醇和(1S,2S,4R,8R)-薄荷烷-1,2,9-三醇。通过光谱分析确定了这些化合物的结构，它们在低于 1.0mg/mL 的浓度下对微生物（大肠杆菌、金黄色葡萄球菌、枯草芽孢杆菌）的体外生长没有抑制作用。