表达高水平免疫球蛋白结合的CD4 + 小鼠T细胞克隆属于产生白细胞介素4的2型辅助性T细胞亚群。
CD4+ murine T cell clones that express high levels of immunoglobulin binding belong to the interleukin 4-producing T helper cell type 2 subset.
作者信息
Sandor M, Gajewski T, Thorson J, Kemp J D, Fitch F W, Lynch R G
机构信息
Department of Pathology, University of Iowa College of Medicine, Iowa City 52242.
出版信息
J Exp Med. 1990 Jun 1;171(6):2171-6. doi: 10.1084/jem.171.6.2171.
Abstract
A panel of 20 murine CD4+ clones was examined for the presence of surface membrane receptors for IgA, IgM, IgD, IgE, and IgG. High level expression of multiple Fc receptors (FcRs) was found on all Th2 clones. FcR expression was low or undetected on the Th1 clones. The preferential expression of FcR on activated Th2 cells suggests potential mechanisms for immunoregulatory interactions with B cells.
摘要
检测了一组20个小鼠CD4+克隆，以确定其是否存在针对IgA、IgM、IgD、IgE和IgG的表面膜受体。在所有Th2克隆上均发现多种Fc受体（FcR）的高水平表达。在Th1克隆上，FcR表达较低或未检测到。FcR在活化的Th2细胞上的优先表达提示了与B细胞进行免疫调节相互作用的潜在机制。
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