Bennett William M
Northwest Renal Clinic, Transplant Services Legacy Good Samaritan Hospital, Portland, OR 97210, USA.
Korean J Intern Med. 2009 Sep;24(3):165-8. doi: 10.3904/kjim.2009.24.3.165. Epub 2009 Aug 26.
Because autosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic abnormalities seen in today's medical practice, many internists will likely treat patients affected by this condition. Genetic abnormalities have been increasingly recognized, and the pathophysiology of the disease is beginning to be unraveled. Because of advances in imaging technology, surrogate markers for disease progression have allowed clinical studies of newer therapeutic agents to proceed. In the near future, therapies for this common genetic disease may be available to either prevent or stabilize the disease course for many affected individuals.
由于常染色体显性遗传性多囊肾病（ADPKD）是当今医学实践中最常见的基因异常疾病之一，许多内科医生可能会治疗受此疾病影响的患者。基因异常已得到越来越多的认识，并且该疾病的病理生理学也开始被揭示。由于成像技术的进步，疾病进展的替代标志物使得新型治疗药物的临床研究得以进行。在不久的将来，针对这种常见基因疾病的治疗方法可能会出现，从而为许多受影响个体预防疾病或稳定病程。
