Hui C C, Suzuki Y, Kikuchi Y, Mizuno S
Department of Developmental Biology, National Institute for Basic Biology, Okazaki, Japan.
J Mol Biol. 1990 Jun 5;213(3):395-8. doi: 10.1016/S0022-2836(05)80201-3.
Multiple A + T-rich stretches in the 5' flanking region of the Bombyx mori fibroin light-chain gene have been shown to bind two Drosophila homeodomain proteins, EVE (even-skipped) and ZEN (zerknüllt), with high affinities. Some of these sites fall into a class that has the established consensus sequence of the binding sites (TCAATTAAAT) for a diverse group of Drosophila homeodomain proteins, while others are quite heterogenous except that they all possess a core TAAT motif. Since clusters of homeodomain binding sites can also be found in the promoters of other silk protein genes, the fibroin gene and the sericin-1 gene, these observations suggest a possible involvement of some homeobox genes in the regulation of a group of silk protein genes.
家蚕纤维蛋白轻链基因5'侧翼区域中多个富含A + T的片段已被证明能与两种果蝇同源结构域蛋白EVE（偶数缺失）和ZEN（零乱）高亲和力结合。这些位点中的一些属于一类，具有已确定的果蝇同源结构域蛋白结合位点（TCAATTAAAT）的共有序列，而其他位点则相当异质，只是它们都具有核心TAAT基序。由于在其他丝蛋白基因、纤维蛋白基因和丝胶蛋白-1基因的启动子中也能发现同源结构域结合位点簇，这些观察结果表明一些同源框基因可能参与了一组丝蛋白基因的调控。
