Oliva Maria Luiza V, Sampaio Misako U
Departamento de Bioquímica, Universidade Federal de São Paulo, Escola Paulista de Medicina, Rua Três de Maio, 100, 04044-020 São Paulo, SP, Brasil.
An Acad Bras Cienc. 2009 Sep;81(3):615-21. doi: 10.1590/s0001-37652009000300023.
Obtained from leguminous seeds, various plant proteins inhibit animal proteinases, including human, and can be considered for the development of compounds with biological activity. Inhibitors from the Bowman-Birk and plant Kunitz-type family have been characterized by proteinase specificity, primary structure and reactive site. Our group mostly studies the genus Bauhinia, mainly the species bauhinioides, rufa, ungulata and variegata. In some species, more than one inhibitor was characterized, exhibiting different properties. Although proteins from this group share high structural similarity, they present differences in proteinase inhibition, explored in studies using diverse biological models.
从豆科种子中获得的各种植物蛋白可抑制包括人类在内的动物蛋白酶，可考虑用于开发具有生物活性的化合物。来自鲍曼-伯克和植物库尼茨型家族的抑制剂已通过蛋白酶特异性、一级结构和反应位点进行了表征。我们的团队主要研究羊蹄甲属，主要是拟羊蹄甲、红羊蹄甲、蹄甲和洋紫荆等物种。在一些物种中，鉴定出了不止一种抑制剂，它们表现出不同的特性。尽管该组中的蛋白质具有高度的结构相似性，但在使用不同生物模型的研究中发现它们在蛋白酶抑制方面存在差异。
