妊娠与多发性硬化症：来自巴西数据库的初步结果。
Pregnancy and multiple sclerosis: the initial results from a Brazilian database.
作者信息
Fragoso Yara Dadalti, Finkelsztejn Alessandro, Comini-Frota Elizabeth Regina, da Gama Paulo Diniz, Grzesiuk Ansderson Kuntz, Khouri Jussara Mathias Netto, Alves-Leon Soniza Vieira, Morales Rogério de Rizo, Lana-Peixoto Marco Aurélio, Rocha Cristiane Franklin da
机构信息
Universidade Metropolitana de Santos, Santos, SP, Brazil.
出版信息
Arq Neuropsiquiatr. 2009 Sep;67(3A):657-60. doi: 10.1590/s0004-282x2009000400015.
PURPOSE
Pregnancy management poses an extra challenge to physicians and their multiple sclerosis (MS) patients. There are few papers reporting databases on the subject.
METHOD
Brazilian database from nine MS clinical and research units, with complete data on 47 pregnant women (49 pregnancies).
RESULTS
Despite relatively high exposure to MS medications, no birth defects were reported. Low birth weight and prematurity were similar to those for developing countries. Three complications may have been associated with these medications, while three others were considered to be of purely obstetric nature.
CONCLUSION
Our results confirm previous findings on lower relapse rate during pregnancy and add to the present literature informing on data related to drug exposure.
目的
妊娠管理给医生及其多发性硬化症（MS）患者带来了额外挑战。关于该主题的数据库报告较少。
方法
来自巴西九个MS临床和研究单位的数据库，有47名孕妇（49次妊娠）的完整数据。
结果
尽管相对较高地暴露于MS药物，但未报告出生缺陷。低出生体重和早产情况与发展中国家相似。三种并发症可能与这些药物有关，而另外三种被认为纯粹是产科性质的。
结论
我们的结果证实了先前关于孕期复发率较低的发现，并为当前有关药物暴露数据的文献增添了内容。
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