Kintz P, Tracqui A, Lugnier A J, Mangin P, Chaumont A A
Institut de Médecine Légale, Strasbourg, France.
Methods Find Exp Clin Pharmacol. 1990 Apr;12(3):193-6.
This paper describes a procedure for the quantitative determination of alfentanil, dextromoramide, fentanyl, methadone, pentazocine, pethidine, phenoperidine and phencyclidine in human plasma. Some drug metabolites were included in the study. The procedure involves a simple alkaline extraction technique and capillary gas chromatography separation followed by a nitrogen-selective detection. Concentrations as low as 10 micrograms/l can be routinely evaluated, making this method suitable for use in overdose drug screening, therapeutic drug monitoring and pharmacokinetic studies.
本文描述了一种用于定量测定人血浆中阿芬太尼、右吗拉胺、芬太尼、美沙酮、喷他佐辛、哌替啶、苯哌利定和苯环己哌啶的方法。研究中纳入了一些药物代谢物。该方法采用简单的碱性萃取技术和毛细管气相色谱分离，随后进行氮选择性检测。常规情况下可评估低至10微克/升的浓度，这使得该方法适用于药物过量筛查、治疗药物监测和药代动力学研究。
