Schestatsky Pedro, Nascimento Osvaldo José M
Department of Neurology, Hospital de Clínicas de Porto Alegre, Porto Alegre, RS, Brazil.
Arq Neuropsiquiatr. 2009 Sep;67(3A):741-9. doi: 10.1590/s0004-282x2009000400039.
Neuropathic pain (NP) is defined as pain caused by lesion or dysfunction of the somatosensory system, as a result of abnormal activation of the nociceptive pathway (small fibers and spinothalamic tracts). The most common causes of this syndrome are the following: diabetes, post-herpetic neuralgia, trigeminal neuralgia, stroke, multiple sclerosis, spinal cord injury, HIV infection, cancer. In the last few years, the NP has been receiving special attention for two main reasons: (1) therapeutical refractoriness of a variety of pain syndromes with predominant neuropathic characteristics and (2) the development of diagnostic tools for neuropathic pain complaints. The present review article provides relevant information on the understanding and recognition of NP, as well as evidence-based therapeutic approaches.
神经病理性疼痛（NP）被定义为由躯体感觉系统的损伤或功能障碍引起的疼痛，是伤害性感受通路（小纤维和脊髓丘脑束）异常激活的结果。该综合征最常见的病因如下：糖尿病、带状疱疹后神经痛、三叉神经痛、中风、多发性硬化症、脊髓损伤、HIV感染、癌症。在过去几年中，NP因其两个主要原因而受到特别关注：（1）多种以神经病理性特征为主的疼痛综合征的治疗难治性；（2）针对神经病理性疼痛主诉的诊断工具的发展。本综述文章提供了有关NP的理解和识别以及循证治疗方法的相关信息。
