咪唑烷酮催化环状α,β-不饱和酮还原反应中立体选择性的起源
Origin of stereoselectivity in the imidazolidinone-catalyzed reductions of cyclic alpha,beta-unsaturated ketones.
作者信息
Gutierrez Osvaldo, Iafe Robert G, Houk K N
机构信息
Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095-1569, USA.
出版信息
Org Lett. 2009 Oct 1;11(19):4298-301. doi: 10.1021/ol901586t.
Abstract
The organocatalytic transfer hydrogenation reactions of 3-phenyl-2-cyclopentenone with imidazolidinone catalysts are evaluated using the hybrid density functional (B3LYP/6-31G(d)) theory. The origin of the preference for the (E) iminium transition state is determined, and the stereoselectivity of hydride transfer is investigated.
摘要
使用杂化密度泛函（B3LYP/6-31G(d)）理论评估了3-苯基-2-环戊烯酮与咪唑烷酮催化剂的有机催化转移氢化反应。确定了（E）亚胺鎓过渡态偏好的起源，并研究了氢化物转移的立体选择性。
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