Heidari M R, Dadollahi Z, Mehrabani M, Mehrabi H, Pourzadeh-Hosseini M, Behravan E, Etemad L
Department of Toxicology and Pharmacology, Faculty of Pharmacy, Pharmaceutics - Neuroscience and Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran.
Ann N Y Acad Sci. 2009 Aug;1171:300-4. doi: 10.1111/j.1749-6632.2009.04917.x.
Matricaria recutita L. is a well-known medicinal plant that is suggested as being carminative, analgesic, and anticonvulsant in traditional medicine. In the present investigation the effect of hydro-methanolic percolated extract of this plant on seizure induced by picrotoxin was studied in male mice. This study was performed on animals pretreated with doses of 100, 200, and 300 mg/kg of extract or 40 mg/kg phenobarbital as the reference drug via intraperitoneal injection. After 20 min each animal received 12 mg/kg picrotoxin for induction of seizure. Latency of onset time of seizure, duration of seizure, death latency, and death rate were determined in experimental and control groups. The results showed that latency of the beginning time of seizure was increased in groups that were pretreated with different doses of extract. The most effective dose was 200 mg/kg (P < 0.05). In addition, this dose delayed the time of death in mice (P < 0.01). The extract had no effect on the death rate. The results indicate that the extract of M. recutita possesses suitable effects on seizure induced by picrotoxin, and more experiments are needed in this field.
母菊是一种著名的药用植物，在传统医学中被认为具有驱风、止痛和抗惊厥作用。在本研究中，对雄性小鼠研究了该植物的氢-甲醇渗漉提取物对印防己毒素诱发惊厥的影响。本研究以腹腔注射100、200和300 mg/kg提取物或40 mg/kg苯巴比妥作为参比药物预处理的动物进行。20分钟后，每只动物接受12 mg/kg印防己毒素以诱发惊厥。测定实验组和对照组惊厥发作起始时间的潜伏期、惊厥持续时间、死亡潜伏期和死亡率。结果表明，用不同剂量提取物预处理的组惊厥开始时间的潜伏期延长。最有效的剂量为200 mg/kg（P<0.05）。此外，该剂量延迟了小鼠的死亡时间（P<0.01）。提取物对死亡率没有影响。结果表明，母菊提取物对印防己毒素诱发的惊厥具有一定作用，该领域还需要更多实验。
