Heinicke E A, Kiernan J A
Department of Anatomy, University of Western Ontario, London, Canada.
J Pharm Pharmacol. 1990 Feb;42(2):123-5. doi: 10.1111/j.2042-7158.1990.tb05366.x.
Earlier reports have suggested that anthraquinone purgatives in excessive amounts cause degeneration of neurons in the enteric nervous system. Danthron (1,8-dihydroxyanthraquinone) was administered to rats in their drinking water for four months. The effects of the drug on the total number of neurons and on the immunoreactivity of eight putative neurotransmitters in the myenteric plexus of the colon have been assessed. No differences were found between the treated animals and their controls, indicating that the drug does not kill myenteric neurons. These results agree with recent observations on the effects of senna in rats and mice, and do not support earlier claims that myenteric neurons are killed by anthraquinone purgatives.
早期报告表明，过量的蒽醌类泻药会导致肠神经系统中的神经元退化。将丹蒽醌（1,8 - 二羟基蒽醌）添加到大鼠饮用水中，持续四个月。评估了该药物对结肠肌间神经丛中神经元总数以及八种假定神经递质免疫反应性的影响。在处理过的动物与其对照组之间未发现差异，这表明该药物不会杀死肌间神经元。这些结果与最近关于番泻叶对大鼠和小鼠影响的观察结果一致，并不支持早期关于肌间神经元会被蒽醌类泻药杀死的说法。
