Galligan J J, Tokimasa T, North R A
Vollum Institute for Advanced Biomedical Research, Oregon Health Sciences University, Portland 97201.
Neurosci Lett. 1987 Nov 23;82(2):167-71. doi: 10.1016/0304-3940(87)90123-6.
The effects of substance P (SP), substance K (SK) and neuromedin K (NMK) were compared on single neurons of the guinea pig myenteric plexus. The tachykinins depolarized all myenteric neurons with a rank order of potency SP greater than SK greater than NMK. In approximately 80% of neurons studies the depolarization was associated with an increase in membrane resistance: in 20% membrane resistance decreased. The depolarizations were not affected by tetrodotoxin (TTX) (300 nM), hyoscine (1 microM) or by [D-Arg1, D-Pro2, D-Trp7,9, Leu11]SP (1 microM). These results provide no evidence for more than one type of tachykinin receptor on myenteric neurons.
比较了P物质（SP）、K物质（SK）和神经介素K（NMK）对豚鼠肠肌间神经丛单个神经元的作用。速激肽使所有肠肌间神经元去极化，其效力顺序为SP＞SK＞NMK。在大约80%的被研究神经元中，去极化与膜电阻增加有关；在20%的神经元中膜电阻降低。去极化不受河豚毒素（TTX）（300 nM）、东莨菪碱（1 μM）或[D-精氨酸1，D-脯氨酸2，D-色氨酸7,9，亮氨酸11]SP（1 μM）的影响。这些结果没有提供证据表明肠肌间神经元上存在不止一种类型的速激肽受体。
