Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI 53792, USA.
Sci Signal. 2009 Sep 1;2(86):ra49. doi: 10.1126/scisignal.2000338.
Chronic inflammation and reactivation of developmental signaling pathways are both hallmarks of adenocarcinomas. However, developmental and inflammatory processes are generally thought of as distinct and are believed to represent separate paths to carcinogenesis. Here, we show that the inflammatory cytokine interleukin-1alpha (IL-1alpha) plays a critical role in prostate development by activating insulin-like growth factor (IGF) signaling; this process is reiterated during inflammatory reactive hyperplasia to elicit epithelial proliferation. The appearance of developmental signals during hyperplasia supports the hypothesis that reactivation of developmental signaling plays a role in the hyperplasic reaction to inflammation and suggests that there may be a conserved link between inflammatory signaling and canonical developmental pathways.
慢性炎症和发育信号通路的重新激活都是腺癌的特征。然而，发育和炎症过程通常被认为是不同的，并且被认为代表了致癌作用的不同途径。在这里，我们表明，炎症细胞因子白细胞介素-1α（IL-1α）通过激活胰岛素样生长因子（IGF）信号在前列腺发育中发挥关键作用；这一过程在炎症反应性增生中反复出现，以引起上皮细胞增殖。增生过程中出现发育信号支持这样一种假说，即发育信号的重新激活在炎症的增生反应中起作用，并表明炎症信号和经典发育途径之间可能存在保守联系。
