Polińska Beata, Matowicka-Karna Joanna, Kemona Halina
Zakład Laboratoryjnej Diagnostyki Klinicznej, Uniwersytet Medyczny w Białymstoku, Białystok.
Postepy Hig Med Dosw (Online). 2009 Aug 18;63:389-94.
Inflammatory bowel disease includes ulcerative colitis and Crohn's disease. It is a group of chronic disorders of unknown etiology characterized by inflammation of the gastrointestinal tract. The etiopathogenesis of inflammatory bowel disease is multifactorial. Recent data show that the development of inflammatory bowel disease is associated with the interplay of genetic, bacterial, and environmental factors and dysregulation of the intestinal immune system. The latest research is focused on the key role of cytokines in inflammatory bowel disease. In patients with inflammatory bowel disease, a number of recruited monocytes and activated macrophages are the source of cytokines in the inflamed alimentary tract mucosa. The role of pro-inflammatory cytokines (IL-1alpha, IL-1beta, IL-2, -6, -8, -12, -17, -23, TNF, IFN) in inflammatory bowel disease is associated with the initiation and progression of ulcerative colitis and Crohn's disease. Anti-inflammatory cytokines (IL-4, -10, -13) also contribute to the pathogenesis of inflammatory bowel disease, decreasing the inflammatory response by down-regulating proinflammatory cytokine production.
炎症性肠病包括溃疡性结肠炎和克罗恩病。它是一组病因不明的慢性疾病，其特征为胃肠道炎症。炎症性肠病的发病机制是多因素的。最近的数据表明，炎症性肠病的发展与遗传、细菌和环境因素的相互作用以及肠道免疫系统失调有关。最新研究聚焦于细胞因子在炎症性肠病中的关键作用。在炎症性肠病患者中，大量募集的单核细胞和活化的巨噬细胞是发炎的消化道黏膜中细胞因子的来源。促炎细胞因子（IL-1α、IL-1β、IL-2、-6、-8、-12、-17、-23、TNF、IFN）在炎症性肠病中的作用与溃疡性结肠炎和克罗恩病的发生及进展相关。抗炎细胞因子（IL-4、-10、-13）也参与炎症性肠病的发病机制，通过下调促炎细胞因子的产生来减轻炎症反应。
