Godala Małgorzata, Gaszyńska Ewelina, Walczak Konrad, Małecka-Wojciesko Ewa
Department of Nutrition and Epidemiology, Medical University of Lodz, 90-752 Lodz, Poland.
Department of Internal Medicine and Nephrodiabetology, Medical University of Lodz, 90-549 Lodz, Poland.
J Clin Med. 2023 Sep 13;12(18):5956. doi: 10.3390/jcm12185956.
Inflammatory bowel diseases (IBD) are characterised by multifactorial and chronic inflammation. Much attention has been paid to immune dysfunction in inflammatory bowel diseases. The aim of this study was to assess the usefulness of serum IL-6, IL-1β and IL-10 in determining the activity and nutritional status in IBD patients. The case-control study was carried out on 82 patients with IBD; the control group consisted of 25 clinically healthy subjects. The serum concentrations of IL-6, IL-1 β and IL-10 were determined by the quantitative sandwich enzyme-linked immunosorbent assay. There were no significant differences in IL-6 and IL-1β levels in UC and CD patients according to disease activity as assessed by the Montreal classification, Partial Mayo Score and CDAI. Significantly higher IL-6 levels were found in patients with low body fat in comparison to patients with normal body fat. Furthermore, significantly higher mean IL-6 levels were observed in patients with excess body fat in comparison to patients with normal body fat, and also in comparison to patients with deficient body fat. IL-6 and IL-1β may provide extra information regarding the nutritional status of IBD patients. IL-10 can be considered a non-invasive biomarker of IBD activity.
炎症性肠病（IBD）的特征是多因素引起的慢性炎症。炎症性肠病中的免疫功能障碍已受到广泛关注。本研究的目的是评估血清白细胞介素-6（IL-6）、白细胞介素-1β（IL-1β）和白细胞介素-10（IL-10）在确定IBD患者疾病活动度和营养状况方面的作用。对82例IBD患者进行了病例对照研究；对照组由25名临床健康受试者组成。采用定量夹心酶联免疫吸附测定法测定血清IL-6、IL-1β和IL-10的浓度。根据蒙特利尔分类法、梅奥部分评分和CDAI评估的疾病活动度，UC和CD患者的IL-6和IL-1β水平无显著差异。与身体脂肪正常的患者相比，身体脂肪低的患者IL-6水平显著更高。此外，与身体脂肪正常的患者相比，身体脂肪过多的患者平均IL-6水平显著更高，与身体脂肪不足的患者相比也是如此。IL-6和IL-1β可能为IBD患者的营养状况提供额外信息。IL-10可被视为IBD活动度的一种非侵入性生物标志物。
