作为亲核试剂的α-重氮羰基化合物的反应的最新进展。
Recent development of reactions with alpha-diazocarbonyl compounds as nucleophiles.
机构信息
Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.
出版信息
Chem Commun (Camb). 2009 Sep 28(36):5350-61. doi: 10.1039/b908378b. Epub 2009 Jul 22.
The nucleophilic addition reaction of diazo-compound derived anions or enolates with electrophilic C=O and C=N bonds have been summarized. The subsequent reactions of the addition products demonstrate diverse reactivities of the diazocarbonyl compounds bearing other functional groups and their potential in organic synthesis. Asymmetric catalysis is also possible with diazocarbonyl compounds as nucleophiles.
总结了重氮化合物衍生的阴离子或烯醇化物与亲电 C=O 和 C=N 键的亲核加成反应。加成产物的后续反应表明了带有其他官能团的二羰烯化合物的不同反应活性及其在有机合成中的潜力。作为亲核试剂的二羰烯化合物也可以进行不对称催化。
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