从α-重氮羰基酯和α-异氰基乙酰胺合成多取代 5-氨基恶唑。
Synthesis of polysubstituted 5-aminooxazoles from alpha-diazocarbonyl esters and alpha-isocyanoacetamides.
机构信息
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P. R. China.
出版信息
Org Lett. 2010 Feb 5;12(3):616-8. doi: 10.1021/ol902850a.
PMID:20050600
Abstract
A novel and efficient reaction for the synthesis of 2-keto-5-aminooxazoles is developed. The entire sequence is realized by simply heating a xylene solution of alpha-diazocarbonyl esters and alpha-isocyanoacetamides without any promoters. A possible mechanism for the entire sequence is proposed.
摘要
开发了一种新颖、高效的合成 2-酮-5-氨基恶唑的反应。通过简单地加热二甲苯溶液中的α-重氮羰基酯和α-异氰基乙酰胺，无需任何促进剂即可实现整个序列。提出了整个序列的可能机制。
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