Tokyo Women's Medical University, Japan.
Acta Ophthalmol. 2010 Dec;88(8):896-900. doi: 10.1111/j.1755-3768.2009.01582.x.
To compare the efficacy of bromfenac sodium ophthalmic solution (BF) and a steroidal solution (ST) administered prophylactically against cystoid macular oedema and anterior-chamber inflammation after phacoemulsification and intraocular lens implantation and to assess macular thickness changes using optical coherence tomography (OCT).
In this prospective study, 62 eyes of 62 patients were randomized to either the BF group (n=31) or the ST group (n =31). The average perifoveal thickness (AFT) was measured by OCT preoperatively, and 1 day and 1, 2, 4 and 6 weeks postoperatively. The best-corrected visual acuity, intraocular pressure and flare in the anterior chamber were recorded at each visit. The same method was used to compare patients with non-proliferative diabetic retinopathy (NPDR) in the BF (n = 16) and ST (n =11) groups.
In the analysis of all patients, flare in the anterior chamber was significantly (p = 0.007) lower in the BF group 2 weeks postoperatively. In patients with NPDR, the anterior chamber flare values were significantly lower in the BF group at 4 weeks (p = 0.0009) and 6 weeks (p = 0.005). The AFT values were significantly lower in the BF group at 4 weeks (p < 0.0001) and 6 weeks (p < 0.0001). No adverse events occurred in either group.
BF suppressed anterior chamber inflammation and increasing retinal thickening after cataract surgery in patients with NPDR.
比较溴芬酸钠眼药水（BF）和皮质类固醇眼药水（ST）在预防白内障超声乳化联合人工晶状体植入术后囊样黄斑水肿和前房炎症的疗效，并通过光学相干断层扫描（OCT）评估黄斑厚度变化。
前瞻性研究中，62 例（62 只眼）患者随机分为 BF 组（n=31）和 ST 组（n=31）。术前、术后 1 天、1 周、2 周、4 周和 6 周通过 OCT 测量平均黄斑中心凹厚度（AFT）。每次就诊时记录最佳矫正视力、眼压和前房闪辉。采用相同方法比较 BF 组（n=16）和 ST 组（n=11）中无增生性糖尿病视网膜病变（NPDR）患者。
在所有患者的分析中，术后 2 周 BF 组前房闪辉明显（p=0.007）降低。在 NPDR 患者中，BF 组在术后 4 周（p=0.0009）和 6 周（p=0.005）时前房闪辉值明显较低。BF 组在术后 4 周（p<0.0001）和 6 周（p<0.0001）时 AFT 值明显较低。两组均未发生不良反应。
BF 可抑制 NPDR 患者白内障术后前房炎症和视网膜增厚。
