Service d'Hormonologie, Hôpital Lapeyronie, CHU Montpellier et UM1, Montpellier, France.
Genome Med. 2009 Aug 25;1(8):81. doi: 10.1186/gm81.
Granulosa cell tumors (GCTs) of the ovary belong to the group of ovarian sex-cord stromal tumors and represent 5 to 10% of ovarian malignancies. GCTs exhibit several morphological, biochemical and hormonal features of normal proliferating pre-ovulatory granulosa cells, such as estrogen biosynthesis. Prognostic factors of this condition are lacking, and alternative treatment options to preserve future fertility are needed. Several groups have shown that two genetic factors implicated in GCTs are of particular interest. The gsp oncogene is a constitutive activating mutation of the prognosis of the tumor. FOXL2 is a transcription factor gene involved in ovarian development and function, whose expression is reduced and which is mutated in the majority of GCTs. FOXL2 appears to play a major role in cell cycle regulation. These recent findings open new pathophysiological insights into GCT development as well as revisitation of granulosa cell and ovarian function.
卵巢颗粒细胞瘤（GCT）属于卵巢性索间质肿瘤，占卵巢恶性肿瘤的 5%至 10%。GCT 具有正常增殖性排卵前颗粒细胞的多种形态、生化和激素特征，如雌激素生物合成。这种疾病缺乏预后因素，需要有保留未来生育能力的替代治疗选择。一些研究小组表明，两种与 GCT 相关的遗传因素特别值得关注。gsp 癌基因是肿瘤预后的组成性激活突变。FOXL2 是一种参与卵巢发育和功能的转录因子基因，其表达减少，并且在大多数 GCT 中发生突变。FOXL2 似乎在细胞周期调节中起主要作用。这些新发现为 GCT 发展提供了新的病理生理学见解，并重新审视了颗粒细胞和卵巢功能。
