Ferris Michelle, Easton Douglas F, Doherty Rebecca J, Briggs Brian Hj, Newman Michelle, Saraf Ifthikhar M, Scambler Sarah, Wagman Lyndon, Wyndham Michael T, Ward Ann, Eeles Rosalind A
Institute of Cancer Research and Royal Marsden NHS Trust, London and Sutton, Surrey, SM2 5NG, UK.
Hered Cancer Clin Pract. 2007 Sep 15;5(3):157-60. doi: 10.1186/1897-4287-5-3-157.
To conduct a pilot population-based study within a general practice catchment area to determine whether the incidence of breast cancer was increased in the Ashkenazi population.
Population-based cohort study.
A single general practice catchment area in North London.
1947 women over the age of 16 who responded to a questionnaire about ethnicity and breast cancer.
Incidence of breast cancer, ethnicity.
This study showed a 1.5-fold (95% CI 0.93-2.39) increase in breast cancer risk in the Ashkenazim compared with the non-Ashkenazi white population. The increased incidence was for both premenopausal and postmenopausal breast cancer (expected incidence pre:post is 1:4 whereas in the Ashkenazim it was 1:1; 51 and 52% of cases respectively). This increase was not shown in the Sephardim. Asians had a reduction in incidence (OR = 0.44; 95% CI 0.10-1.89). Results were adjusted for other risk factors for breast cancer.
This study showed a 1.5-fold increase in breast cancer rates in Ashkenazim compared with the non-Jewish white population when adjusted for age (i.e. corrections were made to allow comparison of age groups) and this is not observed in the Sephardic population. The proportion of premenopausal breast cancer was just over double that of the general population. This is the first general practice population-based study in the UK to address this issue and has implications for general practitioners who care for patients from the Ashkenazi community.
在一个全科医疗服务覆盖区域内开展一项基于人群的试点研究，以确定阿什肯纳兹人群中乳腺癌发病率是否升高。
基于人群的队列研究。
伦敦北部的一个单一全科医疗服务覆盖区域。
1947名16岁以上的女性，她们回应了一份关于种族和乳腺癌的问卷。
乳腺癌发病率、种族。
本研究显示，与非阿什肯纳兹白人人群相比，阿什肯纳兹人群患乳腺癌的风险增加了1.5倍（95%置信区间为0.93 - 2.39）。绝经前和绝经后乳腺癌的发病率均有所增加（预期的绝经前与绝经后发病率之比为1:4，而在阿什肯纳兹人群中为1:1；病例分别占51%和52%）。在西班牙裔犹太人中未观察到这种增加。亚洲人的发病率有所降低（比值比 = 0.44；95%置信区间为0.10 - 1.89）。结果针对其他乳腺癌风险因素进行了调整。
本研究表明，在调整年龄后（即进行校正以允许不同年龄组之间进行比较），与非犹太白人人群相比，阿什肯纳兹人群的乳腺癌发病率增加了1.5倍，而在西班牙裔犹太人中未观察到这种情况。绝经前乳腺癌的比例比普通人群高出一倍多。这是英国第一项基于全科医疗服务人群的研究来解决这一问题，对照顾阿什肯纳兹社区患者的全科医生具有启示意义。
