Steiner W, Laporta M, Chouinard G
Clinical Psychopharmacology Unit, Allan Memorial Institute, Royal Victoria Hospital, Montreal, Quebec, Canada.
Acta Psychiatr Scand. 1990 May;81(5):437-40. doi: 10.1111/j.1600-0447.1990.tb05477.x.
Clinical syndromes thought to arise from neuroleptic-induced dopamine receptor supersensitivity are well described in psychiatry. Tardive dyskinesia may arise from neostriatal supersensitivity and supersensitivity psychosis may arise from mesolimbic supersensitivity in schizophrenics chronically treated with neuroleptics. The authors present 5 cases of supersensitivity psychosis that developed in patients with bipolar affective disorder. The clinical syndrome is described and the implications for the long-term course of bipolar affective disorder are discussed.
在精神病学领域，由抗精神病药物引起的多巴胺受体超敏反应所导致的临床综合征已有详尽描述。迟发性运动障碍可能源于新纹状体超敏反应，而超敏性精神病可能源于长期接受抗精神病药物治疗的精神分裂症患者的中脑边缘系统超敏反应。本文作者报告了5例双相情感障碍患者发生的超敏性精神病病例。文中描述了该临床综合征，并讨论了其对双相情感障碍长期病程的影响。
