Kato K, Watanabe T, Itoh M, Yoshida S, Hoshino N, Itoh K, Sugimura F, Iwasaki A, Matsuo Y, Sawai H
Third Department of Internal Medicine, Nihon University School of Medicine, Tokyo, Japan.
Gastroenterol Jpn. 1990 Jun;25(3):314-9. doi: 10.1007/BF02779444.
We investigated the role of the autonomic nervous system in gastric acid secretion, somatostatin concentration and PAS-positive mucus production in Brunner's glands in cysteamine-induced duodenal ulcer. Vagotomized rats were used. No ulcers occurred in the groups with vagotomies of the hepatoduodenal, truncal or gastric branches after cysteamine administration. However, in the hepatoduodenal branch vagotomized group, there was an increase in gastric acid secretion after cysteamine administration. A similar increase was observed in the control group, but the decreases in somatostatin concentration and PAS-positive mucus seen in the control group were not found in the hepatoduodenal vagotomized group. These results suggest that the hepatoduodenal branch of the vagus nerve might play an important role in the ulcerogenic process of cysteamine-induced duodenal ulcer.
我们研究了自主神经系统在半胱胺诱导的十二指肠溃疡中对胃酸分泌、生长抑素浓度以及Brunner腺中PAS阳性黏液产生的作用。使用了迷走神经切断的大鼠。给予半胱胺后，肝十二指肠、迷走神经干或胃分支迷走神经切断的组均未出现溃疡。然而，在肝十二指肠分支迷走神经切断组中，给予半胱胺后胃酸分泌增加。对照组也观察到了类似的增加，但肝十二指肠分支迷走神经切断组未出现对照组中生长抑素浓度降低和PAS阳性黏液减少的情况。这些结果表明，迷走神经的肝十二指肠分支可能在半胱胺诱导的十二指肠溃疡的致溃疡过程中起重要作用。
