Rosner M H, Vigano M A, Ozato K, Timmons P M, Poirier F, Rigby P W, Staudt L M
Metabolism Branch, National Cancer Institute, Bethesda, Maryland 20892.
Nature. 1990 Jun 21;345(6277):686-92. doi: 10.1038/345686a0.
The murine oct-3 gene encodes a transcription factor containing a POU-specific domain and a homeodomain. In marked contrast to other homeodomain-encoding genes, oct-3 is expressed in the totipotent and pluripotent stem cells of the pregastrulation embryo and is down-regulated during differentiation to endoderm and mesoderm, suggesting that it has a role in early development. The oct-3 gene is also expressed in primordial germ cells and in the female germ line.
小鼠的oct-3基因编码一种转录因子，该转录因子包含一个POU特异性结构域和一个同源结构域。与其他编码同源结构域的基因形成显著对比的是，oct-3在原肠胚形成前胚胎的全能和多能干细胞中表达，并在向内胚层和中胚层分化过程中下调，这表明它在早期发育中发挥作用。oct-3基因也在原始生殖细胞和雌性生殖系中表达。
