Department of Preventive Medicine/Biostatistics and Medical Decision Making, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya, Japan.
J Gastroenterol. 2009;44(12):1165-71. doi: 10.1007/s00535-009-0118-7. Epub 2009 Sep 2.
This study aimed to examine the associations of a RUNX3 T/A polymorphism at exon 1 (Asn18Ile) (rs6672420) and another RUNX3 intronic T/A polymorphism (rs760805) with the risk of gastric cancer together with the risk of H. pylori seropositivity and gastric atrophy in Japanese people.
Study subjects were 583 histologically diagnosed gastric cancer patients and age- and sex-frequency-matched 1,742 control outpatients (among whom 1,637 subjects were eligible for the analyses), who visited Aichi Cancer Center Hospital from 2001 to 2005. Serum pepsinogens were measured to evaluate gastric atrophy.
There was no significant association between the RUNX3 polymorphisms and the seropositivity. Among H. pylori seropositive subjects, we found a significant association between RUNX3 rs760805 polymorphism and the risk of gastric atrophy with the age- and sex-adjusted OR of 1.51 (95% CI 1.11-2.05, P = 0.008) in T/A, 1.59 (95% CI 1.08-2.33, P = 0.019) in A/A, and 1.53 (95% CI 1.14-2.05, P = 0.004) in T/A + A/A, compared with T/T genotype. We found no statistically significant associations between RUNX3 rs6672420 polymorphism and risk of gastric atrophy, nor between these two RUNX3 polymorphisms and the risk of gastric cancer relative to the subjects with gastric atrophy.
Our study results revealed that the RUNX3 intronic T/A polymorphism (rs760805) might modulate the risk of gastric atrophy among H. pylori seropositive subjects, and the RUNX3 T/A polymorphism at exon 1 (rs6672420) had little influence on the risks of H. pylori infection, gastric atrophy or gastric cancer in Japanese people. Further investigation is required to verify our findings.
本研究旨在探讨 RUNX3 外显子 1（Asn18Ile）（rs6672420）上的 T/A 多态性和另一个 RUNX3 内含子 T/A 多态性（rs760805）与胃癌风险以及日本人群中幽门螺杆菌血清阳性和胃萎缩风险的相关性。
研究对象为 583 例组织学诊断为胃癌的患者和年龄及性别匹配的 1742 例门诊对照患者（其中 1637 例符合分析条件），他们于 2001 年至 2005 年期间就诊于爱知县癌症中心医院。测量血清胃蛋白酶原以评估胃萎缩。
RUNX3 多态性与血清阳性率之间无显著相关性。在幽门螺杆菌血清阳性的受试者中，我们发现 RUNX3 rs760805 多态性与胃萎缩风险之间存在显著相关性，年龄和性别调整后的 OR 值分别为 T/A 基因型为 1.51（95%CI 1.11-2.05，P=0.008），A/A 基因型为 1.59（95%CI 1.08-2.33，P=0.019），T/A+A/A 基因型为 1.53（95%CI 1.14-2.05，P=0.004），与 T/T 基因型相比。我们没有发现 RUNX3 rs6672420 多态性与胃萎缩风险之间、以及这两个 RUNX3 多态性与胃萎缩患者的胃癌风险之间存在统计学显著相关性。
我们的研究结果表明，RUNX3 内含子 T/A 多态性（rs760805）可能调节幽门螺杆菌血清阳性者的胃萎缩风险，而 RUNX3 外显子 1（rs6672420）上的 T/A 多态性对日本人群中幽门螺杆菌感染、胃萎缩或胃癌的风险影响不大。需要进一步的研究来验证我们的发现。
