Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, Japan.
J Nat Med. 2010 Jan;64(1):1-8. doi: 10.1007/s11418-009-0354-4. Epub 2009 Aug 29.
Phytochemical investigation of the dried leaves of Fraxinus griffithii collected in Okinawa has led to the isolation of three new secoiridoid glucosides, griffithosides A-C (1-3), and one new iridoid glucoside, 7-epi-7-O-(E)-caffeoylloganic acid (4), along with eight known secoiridoid glucosides (5-12). The structures of these compounds were elucidated by means of NMR, MS, and other spectroscopic techniques, as well as comparison with literature data. The isolated compounds were tested for radical-scavenging activity. Among them, compounds 3, 4, and 7 exhibited substantial radical-scavenging activity.
对在冲绳采集的白蜡树干燥叶片的植物化学研究导致分离出三种新的裂环环烯醚萜葡萄糖苷，即 Griffithosides A-C（1-3），以及一种新的环烯醚萜葡萄糖苷，即 7-epi-7-O-（E）-咖啡酰基龙胆酸（4），以及八种已知的裂环环烯醚萜葡萄糖苷（5-12）。这些化合物的结构通过 NMR、MS 和其他光谱技术以及与文献数据的比较来阐明。对分离得到的化合物进行了自由基清除活性测试。其中，化合物 3、4 和 7 表现出显著的自由基清除活性。
