Sridhar Chenchugari, Subbaraju Gottumukkala V, Venkateswarlu Yenamandra, Venugopal Raju T
Department of Pharmaceutical Chemistry, Sri Padmavathi School of Pharmacy, Tirupati-517 507, India.
J Nat Prod. 2004 Dec;67(12):2012-6. doi: 10.1021/np040117r.
Six new iridoid glucosides, 6'-O-trans-feruloylnegundoside (1), 6'-O-trans-caffeoylnegundoside (2), 2'-O-p-hydroxybenzoyl-6'-O-trans-caffeoylgardoside (3), 2'-O-p-hydroxybenzoyl-6'-O-trans-caffeoyl-8-epiloganic acid (4), 2'-O-p-hydroxybenzoyl gardoside (5), and 2'-O-p-hydroxybenzoyl-8-epiloganic acid (6), along with two known iridoids, agnuside and negundoside, have been isolated from the ethyl acetate extractive of the leaves of Vitex altissima. The structures of these compounds were elucidated on the basis of spectral data interpretation. These isolates did not exhibit significant 5-lipoxygenase enzyme inhibitory activity, but compounds 2-4 showed potent antioxidant activity by both the superoxide (NBT riboflavin photoreduction) free-radical-scavenging and DPPH-radical-scavenging methods. Compounds 1, 2, and negundoside were evaluated in a rat paw edema assay.
从高坡黄荆叶的乙酸乙酯提取物中分离出6个新的环烯醚萜苷，即6'-O-反式阿魏酰紫珠苷（1）、6'-O-反式咖啡酰紫珠苷（2）、2'-O-对羟基苯甲酰基-6'-O-反式咖啡酰栀子苷（3）、2'-O-对羟基苯甲酰基-6'-O-反式咖啡酰-8-表马钱子酸（4）、2'-O-对羟基苯甲酰基栀子苷（5）和2'-O-对羟基苯甲酰基-8-表马钱子酸（6），以及2个已知的环烯醚萜，即女贞苷和紫珠苷。通过光谱数据分析阐明了这些化合物的结构。这些分离物未表现出显著的5-脂氧合酶抑制活性，但化合物2 - 4通过超氧化物（NBT核黄素光还原）自由基清除法和DPPH自由基清除法显示出较强的抗氧化活性。对化合物1、2和紫珠苷进行了大鼠足爪水肿试验评估。
