Berg M, Hedblad M A, Erhardt K
Department of Dermatology, Karolinska Hospital, Stockholm, Sweden.
Acta Derm Venereol. 1990;70(3):216-20.
Facial punch biopsies from 83 patients with skin complaints with or without skin lesions and supposedly associated with work at visual display units (VDUs) were compared to biopsies from 51 subjects with no VDU exposure with or without skin lesions. Coded slides were assessed by three independent observers regarding hyperplasia of sebaceous glands, occurrence of telangiectases, intensity of inflammatory infiltrate, degree of hydropic degeneration of basal cells, occurrence of demodex folliculorum, number of mast cells and degree of degenerative changes in elastic fibers. No parameter was significantly more common in exposed subjects than in non-exposed persons with equivalent skin signs. The controls without skin lesions also showed various degrees of histologic changes. Hyperplasia of sebaceous glands was more common in men and in young persons. Degenerative changes in elastic fibers increased with age, but were also obvious in some persons under 35 years of age. In this study no characteristic histologic changes in facial skin were found in individuals with skin symptoms claimed to be associated with exposure to VDUs.
对83例有或无皮肤损害且据推测与视觉显示终端（VDU）工作相关的皮肤疾病患者进行面部打孔活检，并与51例有或无皮肤损害且未接触VDU的受试者的活检结果进行比较。三位独立观察者对编码玻片进行评估，内容包括皮脂腺增生、毛细血管扩张的发生情况、炎症浸润强度、基底细胞水肿变性程度、毛囊蠕形螨的出现情况、肥大细胞数量以及弹性纤维的退行性变程度。在有相同皮肤体征的暴露组受试者中，没有任何参数比未暴露组更常见。无皮肤损害的对照组也表现出不同程度的组织学变化。皮脂腺增生在男性和年轻人中更为常见。弹性纤维的退行性变随年龄增长而增加，但在一些35岁以下的人群中也很明显。在这项研究中，对于声称与VDU暴露相关的皮肤症状个体，未发现面部皮肤有特征性组织学变化。
