Medicinal & Natural Product Chemistry Research Centre, Shiraz University of Medical Sciences, P.O. Box 71345-3288, Shiraz, Iran.
Drug Discov Today. 2009 Nov;14(21-22):1058-66. doi: 10.1016/j.drudis.2009.08.004. Epub 2009 Sep 1.
The 1,4-dihydropyridines (DHPs), a class of drugs, possess a wide variety of biological and pharmacological actions, have represented one of the most important groups of calcium-channel-modulating agents and have experienced widespread use in the treatment of cardiovascular disease. Moreover, it has been demonstrated that DHPs could prove to be highly important as multidrug-resistance-reversing agents in cancer chemotherapy. Recent reports suggest that this class also has other notable activities, particularly as antimycobacterial and anticonvulsant agents. Finally, it might be possible for the DHP motif to serve as a scaffold for other pharmacological applications.
1,4-二氢吡啶（DHPs）类药物具有广泛的生物学和药理学作用，是一类重要的钙通道调节剂，已广泛用于心血管疾病的治疗。此外，DHPs 已被证明在癌症化疗中作为多药耐药逆转剂可能具有重要意义。最近的报告表明，该类药物还具有其他显著的活性，特别是作为抗分枝杆菌和抗惊厥药物。最后，DHPs 可能成为其他药理学应用的支架。
