Khedkar Samrat A, Auti Pratibha B
Department of Pharmaceutical Chemistry, STES's Sinhgad Institute of Pharmacy, Narhe, Pune-41. Maharashtra. India.
Mini Rev Med Chem. 2014;14(3):282-90.
The 1, 4-dihydropyridines (DHPs), a class of drugs possess a wide variety of biological and pharmacological actions. It represents one of the most important groups of calcium-channel modulating agents and has experienced widespread use in the treatment of cardiovascular disease which includes antihypertensive, antianginal, vasodilator and cardiac depressants activities. It also shows antibacterial, anticancer, antileishmanial, anticoagulant, anticonvulsant, antitubercular, antioxidant, antiulcer, CFTR, antimalarials, neuroprotection properties, HIV-1 protease inhibitors, antifertility activities and many more. There are many drugs available in market which contains 1, 4-dihydropyridines ring as basic scaffold. Basic motive of this review is to disclose various therapeutic applications of 1, 4-dihydropyridine derivatives reported by other researchers during their research work in 2001 to 2011.
1,4-二氢吡啶类（DHPs）是一类具有广泛生物学和药理作用的药物。它是最重要的钙通道调节剂组分之一，已广泛用于治疗心血管疾病，包括抗高血压、抗心绞痛、血管舒张和心脏抑制活性。它还具有抗菌、抗癌、抗利什曼原虫、抗凝、抗惊厥、抗结核、抗氧化、抗溃疡、CFTR、抗疟疾、神经保护特性、HIV-1蛋白酶抑制剂、抗生育活性等等。市场上有许多以1,4-二氢吡啶环为基本骨架的药物。本综述的基本目的是揭示其他研究人员在2001年至2011年的研究工作中报道的1,4-二氢吡啶衍生物的各种治疗应用。
