Amor N, Zänker P P, Blümler P, Meise F M, Schreiber L M, Scholz A, Schmiedeskamp J, Spiess H W, Münnemann K
Max Planck Institute for Polymer Research, 55128 Mainz, Germany.
J Magn Reson. 2009 Nov;201(1):93-9. doi: 10.1016/j.jmr.2009.08.004. Epub 2009 Aug 14.
A technique for continuous production of solutions containing hyperpolarized (129)Xe is explored for MRI applications. The method is based on hollow fiber membranes which inhibit the formation of foams and bubbles. A systematic analysis of various carrier agents for hyperpolarized (129)Xe has been carried out, which are applicable as contrast agents for in vivo MRI. The image quality of different hyperpolarized Xe solutions is compared and MRI results obtained in a clinical as well as in a nonclinical MRI setting are provided. Moreover, we demonstrate the application of (129)Xe contrast agents produced with our dissolution method for lung MRI by imaging hyperpolarized (129)Xe that has been both dissolved in and outgassed from a carrier liquid in a lung phantom, illustrating its potential for the measurement of lung perfusion and ventilation.
本文探索了一种用于磁共振成像（MRI）应用的连续生产含超极化（129）Xe溶液的技术。该方法基于中空纤维膜，可抑制泡沫和气泡的形成。已对多种用于超极化（129）Xe的载剂进行了系统分析，这些载剂可用作体内MRI的造影剂。比较了不同超极化Xe溶液的图像质量，并提供了在临床和非临床MRI环境中获得的MRI结果。此外，我们通过对肺模型中已溶解于载液并从载液中脱气的超极化（129）Xe进行成像，展示了用我们的溶解方法生产的（129）Xe造影剂在肺部MRI中的应用，说明了其在测量肺灌注和通气方面的潜力。
