Institute for Technical and Macromolecular Chemistry, RWTH Aachen University, Worringer Weg 1, 52074 Aachen, Germany.
Chemphyschem. 2011 Nov 18;12(16):2941-7. doi: 10.1002/cphc.201100446. Epub 2011 Oct 12.
Magnetic resonance of hyperpolarized (129)Xe has found a wide field of applications in the analysis of biologically relevant fluids. Recently, it has been shown that the dissolution of hyperpolarized gas into the fluid via hollow-fiber membranes leads to bubble-free (129)Xe augmentation, and thus to an enhanced signal. In addition, hollow-fiber membranes permit a continuous operation mode. Herein, a quantitative magnetic resonance imaging and spectroscopy analysis of a customized hollow-fiber membrane module is presented. Different commercial hollow-fiber membrane types are compared with regard to their (129)Xe dissolution efficiency into porcine blood, its constituents, and other fluids. The presented study gives new insight into the suitability of these hollow-fiber membrane types for hyperpolarized gas dissolution setups.
超极化 (129)Xe 的磁共振在分析与生物相关的流体方面有广泛的应用。最近，已经证明通过中空纤维膜将超极化气体溶解到流体中会导致无泡 (129)Xe 增强，从而增强信号。此外，中空纤维膜允许连续操作模式。本文介绍了定制的中空纤维膜模块的定量磁共振成像和光谱分析。比较了不同商业类型的中空纤维膜在将 (129)Xe 溶解到猪血液及其成分和其他流体中的效率。该研究为这些中空纤维膜类型在超极化气体溶解装置中的适用性提供了新的见解。
