Manmaru S, Matsuura M
Department of Neuropsychiatry, Faculty of Medicine, Tokyo Medical and Dental University.
Jpn J Psychiatry Neurol. 1990 Mar;44(1):85-90. doi: 10.1111/j.1440-1819.1990.tb00445.x.
EEGs were recorded for Fp1, C3 and O1 once a week for 4 weeks after the withdrawal of medazepam, a benzodiazepine with a long half-life, from 7 normal males. Quantified analyses of them showed 2 types of change: A maximum change during the administration of medazepam that later tapered off. It consisted mainly of an increase in fast wave, and was uniform across areas though most significant in C3. A rebound phenomenon that reversed the change produced by the drug, the decrease in fast wave being significant in C3 during week 2. These results suggest that fast wave is the most sensitive EEG element and these 2 types of change must be investigated hereafter in terms of significant changes after the discontinuation of medazepam.
从7名正常男性身上撤下半衰期较长的苯二氮䓬类药物美达西泮后，连续4周每周记录一次Fp1、C3和O1的脑电图。对这些脑电图的定量分析显示出两种变化类型：一种是在美达西泮给药期间出现最大变化，随后逐渐减弱。这种变化主要表现为快波增加，各区域变化一致，尽管在C3区域最为显著。另一种是反跳现象，它逆转了药物产生的变化，在第2周时C3区域的快波减少显著。这些结果表明，快波是脑电图中最敏感的元素，今后必须就美达西泮停药后的显著变化对这两种变化类型进行研究。
