Tyutyulkova N, Gorancheva J, Stefanova D, Yanev S, Katzov G, Georgiev A
Methods Find Exp Clin Pharmacol. 1986 Dec;8(12):711-3.
The effect of medazepam in a model of isolation aggression in mice was studied according to Yen et al. It was established that the mean effective dose of medazepam was 250 micrograms/kg and the therapeutic index (LD50:ED50) 6200. The simultaneous biochemical investigations showed a reduction of the affinity and number of benzodiazepine receptors in the brain of aggressive animals. Medazepam 10 mg/kg p.o. led to the restoration of the number of benzodiazepine receptors at a single and 10-day treatment.
