Mani G S, Clarke B C, Shelton P R
Department of Theoretical Physics, Schuster Laboratory, University of Manchester, U.K.
Proc R Soc Lond B Biol Sci. 1990 May 22;240(1297):15-28. doi: 10.1098/rspb.1990.0024.
We describe a computer model that stimulates a combination of stabilizing and frequency-dependent selection acting on a quantitative character determined by several loci. The results correspond to many features of natural variations at both the phenotypic and genotypic levels. The model is robust, and its results are not strongly dependent either on the nature and shape of the function describing the stabilizing selection, or on the precise form of frequency dependence, except near the extrema. It suggests a mechanism for the maintenance of large amounts of variability, and shows a relation between population size and heterozygosity roughly corresponding to that found in nature. In this respect it is unlike the purely neutral model.
我们描述了一种计算机模型，该模型模拟了对由多个基因座决定的数量性状起作用的稳定选择和频率依赖选择的组合。结果在表型和基因型水平上都与自然变异的许多特征相符。该模型很稳健，其结果并不强烈依赖于描述稳定选择的函数的性质和形状，也不依赖于频率依赖的精确形式，除了在极值附近。它提出了一种维持大量变异性的机制，并显示了种群大小与杂合性之间的关系，大致与自然界中发现的关系相符。在这方面，它不同于纯粹的中性模型。
