糖皮质激素在哮喘中的疗效：是否在抗炎上游改善组织重塑。
Glucocorticoid efficacy in asthma: is improved tissue remodeling upstream of anti-inflammation.
作者信息
Freishtat Robert J, Nagaraju Kanneboyina, Jusko William, Hoffman Eric P
机构信息
Children's National Medical Center, Washington, DC 20010, USA.
出版信息
J Investig Med. 2010 Jan;58(1):19-22. doi: 10.2310/JIM.0b013e3181b91654.
Abstract
Synthetic glucocorticoids (GCs), such as prednisone, are among the most widely prescribed drugs worldwide and are used to treat many acute and chronic inflammatory conditions. The current paradigm of GC efficacy is that they are potent anti-inflammatory agents. Decreased inflammation in many disorders is thought to lead to decreased pathological tissue remodeling. However, this model has never been validated. In particular, improvements in inflammation have not been shown to improve the rate of lung function decline in asthma. Herein, we present an alternative paradigm, where GC efficacy is mediated through more successful tissue remodeling, with reduction in inflammation secondary to successful regeneration.
摘要
合成糖皮质激素（GCs），如泼尼松，是全球处方最广泛的药物之一，用于治疗许多急慢性炎症性疾病。目前关于GCs疗效的范例是它们是强效抗炎剂。许多疾病中炎症的减轻被认为会导致病理性组织重塑的减少。然而，这个模型从未得到验证。特别是，炎症的改善并未显示能提高哮喘患者肺功能下降的速率。在此，我们提出一种替代范例，即GCs的疗效是通过更成功的组织重塑介导的，炎症的减轻是成功再生的继发结果。
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