囊胚移植与性别：体外受精与卵胞浆内单精子注射
Blastocyst transfer and gender: IVF versus ICSI.
作者信息
Hentemann Martha Agnes, Briskemyr Siri, Bertheussen Kjell
机构信息
Department of Obstetrics and Gynecology, IVF-unit, University Hospital of Northern Norway, and Institute of Clinical Medicine, University of Tromsø, Tromsø, Norway,
出版信息
J Assist Reprod Genet. 2009 Aug;26(8):433-6. doi: 10.1007/s10815-009-9337-3.
Abstract
PURPOSE
To investigate the difference in sex ratio in our centre after day 5 embryo transfer among neonates delivered after fresh in vitro fertilization (IVF), fresh intra cytoplasmatic sperminjection (ICSI) and frozen embryo replacement (FER) compared to expected sex ratio in normal population.
METHODS
Retrospective data after IVF/ICSI/FER therapy from 1995 - 2007 and data from the literature on similar subjects.
RESULTS
Among a total of 420 births after day 5 transfer, there were 225 male and 195 female babies. However, after ICSI alone 30 were female and 21 male. Adding all available data from the literature on gender ratio after long term culture, the ratio of male births to total births (0.545) was significantly (p = 0.004) different from the expected ratio (0.515).
CONCLUSIONS
It appears that significantly more males are born than expected after day 5 transfer in IVF. However, a subgroup analysis in our data comparing IVF, ICSI and FER revealed more females born after ICSI and FER, suggesting that further research is needed in this area.
摘要
目的
研究在本中心，与正常人群的预期性别比相比，新鲜体外受精（IVF）、新鲜卵胞浆内单精子注射（ICSI）和冻融胚胎移植（FER）后第5天胚胎移植分娩的新生儿的性别比差异。
方法
回顾1995年至2007年IVF/ICSI/FER治疗后的回顾性数据以及关于类似主题的文献数据。
结果
在第5天移植后的420例分娩中，有225例男婴和195例女婴。然而，仅ICSI后有30例女婴和21例男婴。加上文献中所有关于长期培养后性别比的可用数据，男婴出生数与总出生数的比例（0.545）与预期比例（0.515）有显著差异（p = 0.004）。
结论
在IVF中，第5天移植后出生的男婴似乎明显多于预期。然而，我们的数据中对IVF、ICSI和FER进行的亚组分析显示，ICSI和FER后出生的女婴更多，这表明该领域需要进一步研究。
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本文引用的文献
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Are tests of sperm DNA damage clinically useful? Pros and cons.精子DNA损伤检测在临床上有用吗？利弊分析。
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Blastocyst transfer does not cause a sex-ratio imbalance.囊胚移植不会导致性别比例失衡。
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Sperm DNA damage is associated with an increased risk of pregnancy loss after IVF and ICSI: systematic review and meta-analysis.精子DNA损伤与体外受精和卵胞浆内单精子注射后流产风险增加相关：系统评价与荟萃分析
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Blastocyst embryo transfer is associated with a sex-ratio imbalance in favor of male offspring.囊胚胚胎移植与有利于男性后代的性别比例失衡有关。
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