大鼠脑、垂体和肾上腺中多巴胺D-2受体与多巴胺和cAMP调节的磷酸蛋白-32的基因表达比较。
Comparison of gene expression of the dopamine D-2 receptor and DARPP-32 in rat brain, pituitary and adrenal gland.
作者信息
Schalling M, Dagerlind A, Goldstein M, Ehrlich M, Greengard P, Hökfelt T
机构信息
Department of Histology and Neurobiology, Karolinska Institute, Stockholm, Sweden.
出版信息
Eur J Pharmacol. 1990 Apr 25;188(4-5):277-81. doi: 10.1016/0922-4106(90)90012-m.
In situ hybridization histochemistry was used to compare the distribution of dopamine D-2 receptor mRNA and DARPP-32 mRNA in rat brain, pituitary and adrenal gland. In many regions such as the caudate nucleus, nucleus accumbens and olfactory tubercle, there was an excellent correlation with dopamine receptor binding studies, whereas in some discrete brain regions mismatches were observed.
采用原位杂交组织化学方法比较大鼠脑、垂体和肾上腺中多巴胺D-2受体mRNA和多巴胺与3',5'-环磷酸腺苷调节的磷酸蛋白-32（DARPP-32）mRNA的分布。在许多脑区，如尾状核、伏隔核和嗅结节，其结果与多巴胺受体结合研究结果具有很好的相关性，而在一些离散的脑区则观察到不匹配的情况。
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